On October 8, Commordore Rodgers left Boston on his second cruise. The American squadron consisted of the USS President, USS United States, USS Congress, and the USS Argus. After only 4 days, the United States and the Argus separated from Commodore Rogers.

The Argus, commanded by Capt. Sinclair sailed east capturing 6 valuable merchant men and returned to port on January 3. During this cruise, the Argus was pursued for 3 days and 3 nights by a British squadron. The crew of the Argus made the ship lighter so it would sail faster. After getting rid of the ships anchors and boats, the Argus was able to pull away.