Many have claimed the Justinianic Plague (c. 541-750 CE) killed half of the population of Roman Empire. Now, historical research and mathematical modeling challenge the death rate and severity of this first plague pandemic.
Researchers Lauren White, Ph.D. and Lee Mordechai, Ph.D., of the University of Maryland's National Socio-Environmental Synthesis Center (SESYNC), examined the impacts of the Justinianic Plague with mathematical modeling. Using modern plague research as their basis, the two developed novel mathematical models to re-examine primary sources from the time of the Justinianic Plague outbreak. From the modeling, they found that it was unlikely that any transmission route of the plague would have had both the mortality rate and duration described in the primary sources. Their findings appear in a paper titled "Modeling the Justinianic Plague: Comparing hypothesized transmission routes" in PLOS ONE.