USS Cyclops (AC-4) was the second of four Proteus-class colliers built for the United States Navy several years before World War I. Named after the Cyclops, a race of giants from Greek mythology, she was the second U.S. naval vessel to bear the name. The loss of the ship and 306 crew and passengers without a trace occurred sometime after 4 March 1918 and remains the single largest loss of life in the history of the United States Navy not directly involving combat.